antiarrhythmic drugs การใช้

• Ibutilide, like other class III antiarrhythmic drugs, blocks delayed rectified potassium current.
• All patients had previously not responded to an antiarrhythmic drug called procainamide.
• It is a Class III antiarrhythmic agent, whereas procainamide is a Class Ia antiarrhythmic drug.
• This combination of atrial fibrillation and WPW is considered dangerous, and most antiarrhythmic drugs are contraindicated.
• Therapeutic modalities employed in this field include antiarrhythmic drug therapy and surgical implantation of pacemakers and implantable cardioverter-defibrillators.
• Reducing frequent PVC ( > 20 % ) by antiarrhythmic drugs or by catheter ablation significantly improves heart performance.
• To have a high efficacy, the antiarrhythmic drug procainamide has to be dosed frequently to maintain an adequate serum concentration.
• The Jod-Basedow effect also been seen as a side effect of administration of the iodine-containing contrast agents, or amiodarone, an antiarrhythmic drug.
• Further, calcium channel blockers ( verapamil ) and antiarrhythmic drugs may be used as an adjunct therapy to ?-blockers in symptomatic children.
• Due to the irregular rhythm occurring in the atria, targeting them with antiarrhythmic drugs without affecting the ventricles would provide a desirable outcome.
• It is not FDA approved for human use as an antiarrhythmic agent, and it is not included in the Vaughn Williams classification of antiarrhythmic drugs.
• They focused on the unique effects of antiarrhythmic drugs in ischemic tissue, ion sensitive electrodes to understand the heart's electrical activity, and cost-effectiveness in heart disease.
• Originally discovered in 1960, sotalol became widely used first as a beta blocker in the 1980s, and its function as an antiarrhythmic drug was discovered soon after.
• Whichever method of cardioversion is used, approximately 50 % of patients relapse within one year, although the continued daily use of oral antiarrhythmic drugs may extend this period.
• Lack of response to that drug could predict failure of other antiarrhythmic drugs, the editorial said, thus casting some doubt on whether defibrillators actually improve survival of high-risk patients.
• Amiodarone is considered the most effective antiarrhythmic drug available, but its adverse side effects, including hepatic, pulmonary and thyroid toxicity as well as multiple drug interactions, are discouraging its use.
• In a review for " ChemMedChem ", medicinal chemistry professor Ahmed S . Mehanna agreed that " Novel Therapeutic Targets for Antiarrhythmic Drugs " did not adequately cover clinical aspects of drug development.
• Campbell TJ . Kinetics of onset of rate-dependent effects of class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification.
• Hashimoto H, Satoh N, and Nakashima M . Effects of SUN-1165, N-( 2, 6-dimethylphenyl )-8-pyrrolizidine acetamide hydrochloride hemihydrate, a new class I antiarrhythmic drug, on ventricular arrhythmias, intraventricular conduction, and the refractory period in canine myocardial infarction.
• Boissel formulated the hypothesis that the antiarrhythmic drugs efficacy was a function combining a beneficial effect ( \ scriptstyle { a } ) that is proportional to \ scriptstyle { Rc } and a constant adverse effect ( \ scriptstyle { b } ), independent of \ scriptstyle { Rc }.